Journal of the European Optical Society - Rapid publications, Vol 10 (2015)

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Academic innovation: are we truly ready for it?

P. E. Hänninen


Optics has been in the headlines this year due to the UN-sponsored International Year of Light 2015 (IYL 2015), and due to its presence in the 2014 Nobel Prize awards. The purpose of this article is to highlight the innovation-enabling elements that were behind the work of one of the Nobel Laureates - and the stream of innovations that followed, beyond the Nobel work. I will further, from this and my personal experience, expand some thoughts on the enabling elements of academic innovation and draw some conclusions - and, in particular, try and answer the question “How can academic success be repeated?”

© The Authors. All rights reserved. [DOI: 10.2971/jeos.2015.15044i]

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M. Ehrenberg, The Nobel Prize in Chemistry 2014 - Presentation Speech (Stockholm, 2014).

M. Kulomaa, Personal communication (Finland, 2006).

O. H. Meurman, I. A. Hemmilä, T. N. Lövgren, and P. E. Halonen, ”Time-resolved fluoroimmunoassay: a new test for rubella antibodies,” J. Clin. Microbiol. 16, 920–925 (1982).

H. Siitari, I. Hemmilä, E. Soini, T. Lövgren, and V. Koistinen, ”Detection of hepatitis B surface antigen using time-resolved fluoroimFIG. 2 STED nanoscopy of nuclear pore complex substructure in an intact nucleus. Reproduced by courtesy of Abberior Instruments GmbH/Stefan W. Hell (2014). munoassay,” Nature 301 , 258–260 (1983).

P. Halonen, O. Meurman, T. Lövgren, I. Hemmilä, and E. Soini, ”Detection of viral antigens by time-resolved fluoroimmunoassay,” Curr. Top. Microbiol. Immunol. 104, 133–146 (1983).

E. Soini, and H. Kojola, ”Time-resolved fluorometer for lanthanide chelates–a new generation of nonisotopic immunoassays,” Clin. Chem. 29 (1), 65–68 (1983).

N. J. Marshall, S. Dakubu, T. Jackson, and R. P. Ekins, ”Pulsed light, time resolved fluoroimmunoassay,” in Monoclonal antibodies and developments in immunoassay, R. Ekins, and A. Albertini, eds., 101–108 (Elsevier, Amsterdam, 1981).

L. Seveus, M. Vaisala, I. Hemmila, H. Kojola, G. M. Roomans, and E. Soini, ”Use of fluorescent europium chelates as labels in microscopy allows glutaraldehyde fixation and permanent mounting and leads to reduced autofluorescence and good long-term stability,” Microsc. Res. Techniq. 28, 149–154 (1994).

M. Ehrenberg and R. Rigler, ”Fluorescence correlation spectroscopy applied to rotational diffusion of macromolecules,” Q. Rev. Biophys. 9, 69–81 (1976).

R. Rigler, Ü. Mets, J. Widengren, and P. Kask, ”Fluorescence correlation spectroscopy with high count rate and low background: analysis of translational diffusion,” Eur. Biophys. J. 22, 169–175 (1993).

K. Carlsson, P. E. Danielsson, R. Lenz, A. Liljeborg, L. Majlöf, and N. Aslund, ”Three-dimensional microscopy using a confocal laser scanning microscope,” Opt. Lett. 10 (2), 53–55 (1985). 15044i- 4 J. Eur. Opt. Soc.-Rapid 10, 15044i (2015) P. E. Hänninen, et al.

W. E. Moerner and L. Kador, ”Finding a Single Molecule in a Haystack,” Anal. Chem. 61 (21), 1217A–1223A (1989).

S. Weiss, ”Fluorescence spectroscopy of single biomolecules,” Science 283 (5408), 1676–83 (1999).

J . Xie, S. Sreenivasan, G. Korniss, W. Zhang, C. Lim, and B. K. Szymanski, ”Social consensus through the influence of committed minorities,” Phys. Rev. E 84 (1), 011130 (2011).

R. Smith, ”Peer review: a flawed process at the heart of science and journals,” J. Roy. Soc. Med. 99 (4), 178–182 (2006).

”Peer review is fraught with problems, and we need a fix.” [Accessed: 08-Jun-2015].

”The easy way to fix peer review: Require submitters to review first.” _first.html [Accessed: 08-Jun-2015].

P. Hänninen, ”Academy project 4155/4011/92 ‘Confocal Microscopy’ - meeting protocol,” 1994.

M. Häikiö, textslBit Bang: Yrjö Neuvo ja digitaalinen kumous (Yrjö Neuvo and digital revolution (Suomalaisen Kirjallisuuden Seura, Helsinki, 2013) in Finish.

E. H. Stelzer, R. Stricker, R. Pick, C. Storz, and P. Hanninen, ”Confocal Fluorescence Microscopes For Biological Research,” in Proceedings to 1988 International Congress on Optical Science and Engineering, 146–151 (SPIE, Hamburg, 1989).

S. Hell, and E. H. K. Stelzer, ”Fundamental improvement of resolution with a 4Pi-confocal fluorescence microscope using twophoton excitation,” Opt. Commun. 93 (5–6), 277–282 (1992).

P. E. Hänninen, S. W. Hell, J. Salo, E. Soini, and C. Cremer, ”2- Photon Excitation 4Pi Confocal Microscope - Enhanced Axial Resolution Microscope for Biological Research,” Appl. Phys. Lett. 66, 1698–1700 (1995).

W. Denk, J. H. Strickler, and W. W. Webb, ”2-Photon Laser Scanning Fluorescence Microscopy,” Science 248, 73–76 (1990).

P. E. Hanninen, E. Soini, and S. W. Hell, ”Continuous-wave excitation 2-photon fluorescence microscopy,” J. Microsc. 176, 222–225 (1994).

P. E. Hanninen, and S. W. Hell, ”Luminescence-scanning microscopy process and a luminescence scanning microscope utilizing picosecond or greater pulse lasers” U.S. Patent US5777732 (1998).

P. Hänninen, A. Soini, N. Meltola, J. Soini, J. Soukka, and E. Soini, ”A new microvolume technique for bioaffinity assays using twophoton excitation,” Nat. Biotechnol. 18 (5), 548–550, 2000.

P. E. Hänninen, and E. J. Soini, ”A biospecific assay method” WIPO Patent WO1996027798A1 (1996).

P. E. Hänninen, and E. J. Soini, ”Biospecific multiparameter assay method,” U.S. Patent US5891738 (1999).

S. W. Hell, ”Improvement of lateral resolution in far-field fluorescence light microscopy by using two-photon excitation with offset beams,” Opt. Commun. 106 (1–3), 19–24 (1994).

S. W. Hell, and J. Wichmann, ”Breaking the Diffraction Resolution Limity by Stimulated-Emission - Stimulated-Emission-Depletion Fluorescence Microscopy,” Opt. Lett. 19, 780–782 (1994).

S. W. Hell, and M. Kroug, ”Ground-state-depletion fluorscence microscopy: A concept for breaking the diffraction resolution limit,” Appl. Phys. B Lasers O. 60 (5), 495–497 (1995).

P. E. Hänninen, L. Lehtelä, and S. W. Hell, ”Two- and multiphoton excitation of conjugate-dyes using a continuous wave laser,” Opt. Commun. 130, 29–33 (1996).

A. Schonle, P. E. Hanninen, and S. W. Hell, ”Nonlinear fluorescence through intermolecular energy transfer and resolution increase in fluorescence microscopy,” Ann. Phys. 8, 115–133 (1999).

K. I. Willig, B. Harke, R. Medda, and S. W. Hell, ”STED microscopy with continuous wave beams,” Nat. Methods 4, 915–918 (2007).

C. M. Christensen, The Innovator’s Dilemma (Harvard Business School Press, Boston, 1997).

A. Maxmen, ”Taking risks to transform science,” Cell 139 (1), 13–15 (2009).

S. Jobs, ”Text of Steve Jobs’ Commencement address (2005).” [Accessed: 26-Jan-2015].